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Combination therapy is mechanistically plausible but remains insufficiently supported by dedicated randomized evidence in HF populations

Single target Over 68 weeks Typically mild & temporary Two targets stronger signal ~2022% of body weight Over 72 weeks 1 in 3 lost 25%+ Typically mild & temporary All medications are compounded and medically supervised by Eddie Hughes, FNP-BC

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gamma-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor

in 12 HFpEF patients who underwent bariatric surgery, an improvement in Minnesota Living With Heart Failure score (p=0.018), a lowering in LV myocardial mass (p=0.001) and a reduction in NYHA functional class of HF were observed at 3 and 6 months after surgery